アグマチナーゼのソースを表示

{{infobox enzyme
| Name       = アグマチナーゼ
| EC_number  = 3.5.3.11
| CAS_number = 37289-16-0
| GO_code    = 0008783
| image      = 1woi.jpg
| width      = 270
| caption    = [[デイノコッカス・ラディオデュランス]]のアグマチナーゼ六量体
}}
'''アグマチナーゼ'''(Agmatinase, {{EC number|3.5.3.11}})は、以下の[[化学反応]]を[[触媒]]する[[酵素]]である。
:[[アグマチン]] + [[水]] <math>\rightleftharpoons</math> [[プトレシン]] + [[尿素]]

従って、この酵素の基質はアグマチンと水の2つ、生成物はアグマチンと尿素の2つである。

この酵素は、特に[[ペプチド結合]]以外の[[炭素]]-[[窒素]]結合、特に鎖状[[アミジン]]に作用する[[加水分解酵素]]に分類される。系統名は、'''アグマチン アミジノヒドロラーゼ'''(Agmatine amidinohydrolase)である。アグマチンウレオヒドロラーゼ(agmatine ureohydrolase)やSpeBと呼ばれることもある。[[尿素回路]]の一部を構成している。

==遺伝子==
ヒトでは、この酵素は''AGMAT''[[遺伝子]]でコードされている<ref name="pmid11804860">{{cite journal | vauthors = Mistry SK, Burwell TJ, Chambers RM, Rudolph-Owen L, Spaltmann F, Cook WJ, ((Morris SM Jr)) | title = Cloning of human agmatinase. An alternate path for polyamine synthesis induced in liver by hepatitis B virus | journal = Am J Physiol Gastrointest Liver Physiol | volume = 282 | issue = 2 | pages = G375–81 |date=Jan 2002 | pmid = 11804860 | doi = 10.1152/ajpgi.00386.2001 }}</ref><ref name="pmid14648699">{{cite journal | vauthors = Dallmann K, Junker H, Balabanov S, Zimmermann U, Giebel J, Walther R | title = Human agmatinase is diminished in the clear cell type of renal cell carcinoma | journal = Int J Cancer | volume = 108 | issue = 3 | pages = 342–7 |date=Dec 2003 | pmid = 14648699 | doi = 10.1002/ijc.11459 | s2cid = 31927397 | doi-access = free }}</ref><ref name="pmid11914032">{{cite journal | vauthors = Iyer RK, Kim HK, Tsoa RW, Grody WW, Cederbaum SD | title = Cloning and characterization of human agmatinase | journal = Mol Genet Metab | volume = 75 | issue = 3 | pages = 209–18 |date=Mar 2002 | pmid = 11914032 | doi = 10.1006/mgme.2001.3277 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: AGMAT agmatine ureohydrolase (agmatinase)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=79814|accessdate=2023-11-23}}</ref>。

==構造==
2007年5月時点で、5つの[[三次構造]]が解明されている。[[蛋白質構造データバンク]]のアクセッションコードは、{{PDB link|1GQ6}}、{{PDB link|1GQ7}}、{{PDB link|1WOG}}、{{PDB link|1WOH}}及び{{PDB link|1WOI}}である。

==阻害剤==
* [[ピペラジン-1-カルボキシアミジン]]

==出典==
{{Reflist}}
*{{cite journal  | author=Morris SM |title=Vertebrate agmatinases: what role do they play in agmatine catabolism? |journal=Ann. N. Y. Acad. Sci. |volume=1009 |pages= 30–3 |year= 2004 |pmid= 15028567 |doi=10.1196/annals.1304.003  |s2cid=24146429 }}
*{{cite journal  | vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8  }}
*{{cite journal  | vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3  |display-authors=etal}}
*{{cite journal  | vauthors=Chen FW, Davies JP, Ioannou YA |title=Differential gene expression in apoptosis: identification of ribosomal protein 23K, a cell proliferation inhibitor |journal=Mol. Genet. Metab. |volume=64 |issue= 4 |pages= 271–82 |year= 1998 |pmid= 9758718 |doi= 10.1006/mgme.1998.2718 }}
*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |bibcode=2002PNAS...9916899M |display-authors=etal|doi-access=free }}
*{{cite journal  | vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal|doi-access=free }}
*{{cite journal  | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 |display-authors=etal}}
*{{cite journal  | vauthors=Kim KH, Ahn HJ, Kim DJ |title=Expression, crystallization and preliminary X-ray crystallographic analysis of human agmatinase |journal=Acta Crystallographica Section F |volume=61 |issue= Pt 10 |pages= 889–91 |year= 2006 |pmid= 16511187 |doi= 10.1107/S1744309105027193  | pmc=1991308 |display-authors=etal}}
*{{cite journal  | vauthors=Gregory SG, Barlow KF, McLay KE |title=The DNA sequence and biological annotation of human chromosome 1 |journal=Nature |volume=441 |issue= 7091 |pages= 315–21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727 |bibcode=2006Natur.441..315G |display-authors=etal|doi-access=free }}
* {{cite journal | vauthors = Hirshfield IN, Rosenfeld HJ, Leifer Z, Maas WK | date = 1970 | title = Isolation and Characterization of a Mutant of Escherichia coli Blocked in the Synthesis of Putrescine | journal = J. Bacteriol. | volume = 101 | pages = 725&ndash;30  | pmid = 4908780 | issue = 3 | doi = 10.1128/JB.101.3.725-730.1970 | pmc = 250384 }}
* {{cite journal | vauthors = Vicente C, Legaz ME  | date = 1982 | title = Preparation and properties of agmatine amidinohydrolase of Evernia prunastri | journal = Physiol. Plant. | volume = 55 | pages = 335&ndash;339 | doi=10.1111/j.1399-3054.1982.tb00301.x}}
* {{MeshName|agmatinase}}

==外部リンク==
* {{UCSC gene info|AGMAT}}

{{デフォルトソート:あくまちなあせ}}
[[Category:EC 3.5.3]]