クラバミン酸シンターゼのソースを表示

{{enzyme
| Name = クラバミン酸シンターゼ
| EC_number = 1.14.11.21
| CAS_number = 122799-56-8
| IUBMB_EC_number = 1/14/11/21
| GO_code = 0033758
| image = 
| width = 
| caption = 
}}
'''クラバミン酸シンターゼ'''（clavaminate synthase）は、[[クラブラン酸]]生合成酵素の一つで、次の[[化学反応]]を[[触媒]]する[[酸化還元酵素]]である。
:(1) [[デオキシアミジノプロクラバミン酸]] + [[2-オキソグルタル酸]] + [[酸素|O<sub>2</sub>]] <math>\rightleftharpoons</math> [[アミジノプロクラバミン酸]] + [[コハク酸]] + [[二酸化炭素|CO<sub>2</sub>]]
:(2) [[プロクラバミン酸]] + 2-オキソグルタル酸 + O<sub>2</sub> <math>\rightleftharpoons</math> [[ジヒドロクラバミン酸]] + コハク酸 + CO<sub>2</sub> + H<sub>2</sub>O
:(3) ジヒドロクラバミン酸 + 2-オキソグルタル酸 + O<sub>2</sub> <math>\rightleftharpoons</math> [[クラバミン酸]] + コハク酸 + CO<sub>2</sub> + H<sub>2</sub>O

酵素の組織名は'''deoxyamidinoproclavaminate,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating)'''である。

== 参考文献 ==
* {{cite journal | author = Salowe, S.P., Krol, W.J., Iwatareuyl, D. and Townsend, C.A. | date = 1991 | title = Elucidation of the order of oxidations and identification of an intermediate in the multistep clavaminate synthase reaction. | journal = Biochemistry  | volume = 30  | pages = 2281-2292 | pmid = 1998687 }}
* {{cite journal | author = Zhou, J., Gunsior, M., Bachmann, B.O., Townsend, C.A. and Solomon, E.I. | date = 1998 | title = Substrate binding to the α-ketoglutarate-dependent non-heme iron enzyme clavaminate synthase 2: Coupling mechanism of oxidative decarboxylation and hydroxylation.  | journal = J. Am. Chem. Soc.  | volume = 120  | pages = 13539-13540 }}
* {{cite journal | author = Zhang, Z.H., Ren, J.S., Stammers, D.K., Baldwin, J.E., Harlos, K. and Schofield, C.J. | date = 2000 | title = Structural origins of the selectivity of the trifunctional oxygenase clavaminic acid synthase.  | journal = Nat. Struct. Biol.  | volume = 7 | pages = 127-133 | pmid = 10655615 }}
* {{cite journal | author = Zhou, J., Kelly, W.L., Bachmann, B.O., Gunsior, M., Townsend, C.A. and Solomon, E.I.  | date = 2001 | title = Spectroscopic studies of substrate interactions with clavaminate synthase 2, a multifunctional α-KG-dependent non-heme iron enzyme: Correlation with mechanisms and reactivities.  | journal = J. Am. Chem. Soc.  | volume = 123  | pages = 7388-7398}}
* {{cite journal | author = Townsend, C.A.  | date = 2002 | title = New reactions in clavulanic acid biosynthesis.  | journal = Curr. Opin. Chem. Biol.  | volume = 6 | pages = 583-589 | pmid = 12413541 }}

{{デフォルトソート:くらはみんさんしんたせ}}
[[Category:EC 1.14.11]]