ジアミンオキシダーゼのソースを表示

{{enzyme
| Name = ジアミンオキシダーゼ
| EC_number = 1.4.3.22
| CAS_number = 
| IUBMB_EC_number = 1/4/3/22
| GO_code = 0008131
| image = 3k5t.jpg
| width = 270
| caption = 
}}
'''ジアミンオキシダーゼ'''(diamine oxidase)は、[[アルギニン]]、[[プロリン]]、[[ヒスチジン]]、[[トリプトファン]]代謝酵素の一つで、次の[[化学反応]]を[[触媒]]する[[酸化還元酵素]]である。
:ヒスタミン + H<sub>2</sub>O + O<sub>2</sub> <math>\rightleftharpoons</math> (イミダゾール-4-イル)アセトアルデヒド + NH<sub>3</sub> + H<sub>2</sub>O<sub>2</sub>
反応式の通り、この酵素の[[基質]]は[[ヒスタミン]]と[[水|H<sub>2</sub>O]]と[[酸素|O<sub>2</sub>]]、生成物は[[(イミダゾール-4-イル)アセトアルデヒド]]と[[アンモニア|NH<sub>3</sub>]]と[[過酸化水素|H<sub>2</sub>O<sub>2</sub>]]である。

組織名は'''histamine:oxygen oxidoreductase (deaminating)'''で、別名にamine oxidase (ambiguous); amine oxidase (copper-containing) (ambiguous); CAO (ambiguous); Cu-containing amine oxidase (ambiguous); copper amine oxidase (ambiguous); diamine oxidase (ambiguous); diamino oxhydrase (ambiguous); histaminase; histamine deaminase (incorrect); semicarbazide-sensitive amine oxidase (incorrect); SSAO (incorrect)がある。

== 参考文献 ==
* Zeller, E.A. Diamine oxidases. In: Boyer, P.D., Lardy, H. and Myrbäck, K. (Eds), ''The Enzymes'', 2nd edn, vol. 8, Academic Press, New York, 1963, pp. 313-335.
* {{cite journal | author = Crabbe, M.J., Waight, R.D., Bardsley, W.G., Barker, R.W., Kelly, I.D. and Knowles, P.F. | date = 1976| title = Human placental diamine oxidase. Improved purification and characterization of a copper- and manganese-containing amine oxidase with novel substrate specificity.  | journal = Biochem. J.  | volume =155  | pages = 679-687 | pmid = 182134}}
* {{cite journal | author = Chassande, O., Renard, S., Barbry, P. and Lazdunski, M.  | date = 1994| title = The human gene for diamine oxidase, an amiloride binding protein. Molecular cloning, sequencing, and characterization of the promoter.  | journal = J. Biol. Chem. | volume =269  | pages = 14484-14489 | pmid = 8182053}}
* {{cite journal | author = Houen, G. | date = 1999| title = Mammalian Cu-containing amine oxidases (CAOs): new methods of analysis, structural relationships, and possible functions.  | journal = APMIS Suppl.  | volume = 96 | pages = 1-46 | pmid =10668504}}
* {{cite journal | author = Elmore, B.O., Bollinger, J.A. and Dooley, D.M. | date = 2002| title = Human kidney diamine oxidase: heterologous expression, purification, and characterization.  | journal = J. Biol. Inorg. Chem.  | volume = 7 | pages = 565-579 | pmid = 12072962}}

{{DEFAULTSORT:しあみんおきしたせ}}
[[Category:EC 1.4.3]]