ヒダントインラセマーゼのソースを表示

{{Infobox enzyme
| Name = ヒダントインラセマーゼ
| EC_number = 5.1.99.5
| CAS_number = 
| IUBMB_EC_number = 5/1/99/5
| GO_code = 
| image = 
| width = 
| caption =
}}
'''ヒダントインラセマーゼ''' (Hydantoin racemase、{{EC number|5.1.99.5}}) は、以下の[[化学反応]]を[[触媒]]する[[酵素]]である。
:D-5-一置換[[ヒダントイン]] <math>\rightleftharpoons</math> L-5-一置換ヒダントイン

この酵素は、[[異性化酵素]]、特にその他の物質に作用する[[ラセマーゼ]]及び[[エピメラーゼ]]に分類される。系統名は、D-5-一置換ヒダントインラセマーゼ (D-5-monosubstituted-hydantoin racemase) である<ref>{{cite journal | title = Purification and characterization of the hydantoin racemase of ''Pseudomonas'' sp. strain NS671 expressed in ''Escherichia coli'' |author = Watabe, K., Ishikawa, T., Mukohara, Y. and Nakamura, H. |journal = J. Bacteriol. |year = 1992 |volume = 174 |pages = 7989–7995 |pmid = 1459947}}</ref><ref>{{cite journal | title = Hydantoin racemase from ''Arthrobacter aurescens'' DSM 3747: heterologous expression, purification and characterization |author = Wiese, A., Pietzsch, M., Syldatk, C., Mattes, R. and Altenbuchner, J. |journal = J. Biotechnol. |year = 2000 |volume = 80 |pages = 217–230 |pmid = 10949312 |doi=10.1016/s0168-1656(00)00262-5}}</ref><ref>{{cite journal | title = Molecular cloning, purification, and biochemical characterization of hydantoin racemase from the legume symbiont ''Sinorhizobium meliloti'' CECT  4114 |author = Mart&iacute;nez-Rodr&iacute;guez, S., Las Heras-V&aacute;zquez, F.J., Mingorance-Cazorla, L., Clemente-Jim&eacute;nez, J.M. and Rodr&iacute;guez-Vico, F. |journal = Appl. Environ. Microbiol. |year = 2004 |volume = 70 |pages = 625–630 |pmid = 14711700 |doi=10.1128/aem.70.1.625-630.2004}}</ref><ref>{{cite journal | title = Biochemical characterization of a novel hydantoin racemase from ''Agrobacterium tumefaciens'' C58 |author = Mart&iacute;nez-Rodr&iacute;guez, S., Las Heras-V&aacute;zquez, F.J., Clemente-Jim&eacute;nez, J.M. and Rodr&iacute;guez-Vico, F. |journal = Biochimie |year = 2004 |volume = 86 |pages = 77–81 |pmid = 15016445 |doi=10.1016/j.biochi.2004.01.004}}</ref><ref>{{cite journal | title = Purification and characterization of hydantoin racemase from ''Microbacterium liquefaciens'' AJ 3912 |author = Suzuki, S., Onishi, N. and Yokozeki, K. |journal = Biosci. Biotechnol. Biochem. |year = 2005 |volume = 69 |pages = 530–536 |pmid = 15784981 |doi=10.1271/bbb.69.530}}</ref><ref>{{cite journal | title = Site-directed mutagenesis indicates an important role of cysteines 76 and 181 in the catalysis of hydantoin racemase from ''Sinorhizobium meliloti'' |author = Mart&iacute;nez-Rodr&iacute;guez, S., And&uacute;jar-S&aacute;nchez, M., Neira, J.L., Clemente-Jim&eacute;nez, J.M., Jara-P&eacute;rez, V., Rodr&iacute;guez-Vico, F. and Las Heras-V&aacute;zquez, F.J. |journal = Protein Sci. |year = 2006 |volume = 15 |pages = 2729–2738 |pmid = 17132860 |doi=10.1110/ps.062452106}}</ref><ref>{{cite journal | title = Hydantoinases and related enzymes as biocatalysts for the synthesis of unnatural chiral amino acids |author = Altenbuchner, J., Siemann-Herzberg, M. and Syldatk, C. |journal = Curr. Opin. Biotechnol. |year = 2001 |volume = 12 |pages = 559–563 |pmid = 11849938 |doi=10.1016/s0958-1669(01)00263-4}}</ref>。他に、5'-monosubstituted-hydantoin racemase、HyuA、HyuE等とも呼ばれる。

この酵素は「ヒダントイナーゼプロセス」(hydantoinase process) として知られるカスケード反応の一部をなす。

==出典==
{{reflist}}

==外部リンク==
* {{MeshName|Hydantoin+racemase}}

{{デフォルトソート:ひたんといんらせまあせ}}
[[Category:EC 5.1]]