ペプチドデホルミラーゼのソースを表示

{{enzyme
| Name = ペプチドデホルミラーゼ
| EC_number = 3.5.1.88
| CAS_number = 
| IUBMB_EC_number = 3/5/1/88
| GO_code = 0042586
| image = 
| width = 
| caption = 
}}
'''ペプチドデホルミラーゼ'''(Peptide deformylase、{{EC number|3.5.1.88}})は、以下の[[化学反応]]を[[触媒]]する[[酵素]]である。
:ホルミル-L-メチオニルペプチド + 水<math>\rightleftharpoons</math>ギ酸 + メチオニルペプチド

従って、この酵素の基質は[[ホルミル-L-メチオニルペプチド]]と[[水]]の2つ、生成物は[[ギ酸]]と[[メチオニルペプチド]]の2つである。

この酵素は[[加水分解酵素]]、特に鎖状アミドの炭素-窒素結合に作用するものに分類される。系統名は、'''ホルミル-L-メチオニルペプチド アミドヒドロラーゼ'''(formyl-L-methionyl peptide amidohydrolase)である。

==構造==
2007年末時点で、34つの構造が解明されている。[[蛋白質構造データバンク]]のコードは、{{PDB link|1IX1}}、{{PDB link|1LM4}}、{{PDB link|1LM6}}、{{PDB link|1LME}}、{{PDB link|1LQW}}、{{PDB link|1LQY}}、{{PDB link|1LRU}}、{{PDB link|1LRY}}、{{PDB link|1N5N}}、{{PDB link|1Q1Y}}、{{PDB link|1S17}}、{{PDB link|1SV2}}、{{PDB link|1SZZ}}、{{PDB link|1V3Y}}、{{PDB link|1VEV}}、{{PDB link|1VEY}}、{{PDB link|1VEZ}}、{{PDB link|1WS0}}、{{PDB link|1WS1}}、{{PDB link|1XEM}}、{{PDB link|1XEN}}、{{PDB link|1XEO}}、{{PDB link|1Y6H}}、{{PDB link|1ZXZ}}、{{PDB link|1ZY0}}、{{PDB link|1ZY1}}、{{PDB link|2AI7}}、{{PDB link|2AI8}}、{{PDB link|2AI9}}、{{PDB link|2AIA}}、{{PDB link|2AIE}}、{{PDB link|2EW5}}、{{PDB link|2EW6}}及び{{PDB link|2EW7}}である。

==出典==
* {{cite journal | author = Adams JM | year = 1968 | title = On the release of the formyl group from nascent protein | journal = J. Mol. Biol.  | volume = 33 | pages = 571&ndash;89  | pmid = 4973445 | doi = 10.1016/0022-2836(68)90307-0 | issue = 3 }}
* {{cite journal | author = Mazel D, Pochet S, Marliere P | year = 1994 | title = Genetic characterization of polypeptide deformylase, a distinctive enzyme of eubacterial translation | journal = EMBO J.  | volume = 13 | pages = 914&ndash;23  | pmid = 8112305 | issue = 4 | pmc = 394892 }}
* {{cite journal | author = Chan MK, Gong W, Rajagopalan PT, Hao B, Tsai CM, Pei D | year = 1997 | title = Crystal structure of the Escherichia coli peptide deformylase | journal = Biochemistry.  | volume = 36 | pages = 13904&ndash;9  | pmid = 9374869 | doi = 10.1021/bi9711543 | issue = 45 }}
* {{cite journal | author = Becker A, Schlichting I, Kabsch W, Schultz S, Wagner AF | year = 1998 | title = Structure of peptide deformylase and identification of the substrate binding site | journal = J. Biol. Chem.  | volume = 273 | pages = 11413&ndash;6  | pmid = 9565550 | doi = 10.1074/jbc.273.19.11413 | issue = 19 }}
* {{cite journal | author = Becker A, Schlichting I, Kabsch W, Groche D, Schultz S, Wagner AF | year = 1998 | title = Iron center, substrate recognition and mechanism of peptide deformylase | journal = Nat. Struct. Biol.  | volume = 5 | pages = 1053&ndash;8  | pmid = 9846875 | doi = 10.1038/4162 | issue = 12 }}
* {{cite journal | author = Rajagopalan PTR, Yu, XC and Pei D | year = 1997 | title = Peptide deformylase: a new type of mononuclear iron protein | journal = J. Am. Chem. Soc.  | volume = 119 | pages = 12418&ndash;12419 | doi = 10.1021/ja9734096 | issue = 50 }}
* {{cite journal | author = Groche D, Becker A, Schlichting I, Kabsch W, Schultz S, Wagner AF | year = 1998 | title = Isolation and crystallization of functionally competent Escherichia coli peptide deformylase forms containing either iron or nickel in the active site | journal = Biochem. Biophys. Res. Commun.  | volume = 246 | pages = 342&ndash;6  | pmid = 9610360 | doi = 10.1006/bbrc.1998.8616 | issue = 2 }}
* {{cite journal | author = Rajagopalan PT, Grimme S, Pei D | year = 2000 | title = Characterization of cobalt(II)-substituted peptide deformylase: function of the metal ion and the catalytic residue Glu-133 | journal = Biochemistry.  | volume = 39 | pages = 779&ndash;90  | pmid = 10651644 | doi = 10.1021/bi9919899 | issue = 4 }}
* {{cite journal | author = Hu YJ, Wei Y, Zhou Y, Rajagopalan PT, Pei D | year = 1999 | title = Determination of substrate specificity for peptide deformylase through the screening of a combinatorial peptide library | journal = Biochemistry.  | volume = 38 | pages = 643&ndash;50  | pmid = 9888804 | doi = 10.1021/bi9820412 | issue = 2 }}
* {{cite journal | author = Ragusa S, Mouchet P, Lazennec C, Dive V, Meinnel T | year = 1999 | title = Substrate recognition and selectivity of peptide deformylase Similarities and differences with metzincins and thermolysin | journal = J. Mol. Biol.  | volume = 289 | pages = 1445&ndash;57  | pmid = 10373378 | doi = 10.1006/jmbi.1999.2832 | issue = 5 }}
* {{cite journal | author = Giglione C, Pierre M, Meinnel T | year = 2000 | title = Peptide deformylase as a target for new generation, broad spectrum antimicrobial agents | journal = Mol. Microbiol.  | volume = 36 | pages = 1197&ndash;205  | pmid = 10931273 | doi = 10.1046/j.1365-2958.2000.01908.x | issue = 6 }}
* {{cite journal | author = Pei D | year = 2001 | title = Peptide deformylase: a target for novel antibiotics? | journal = Emerging Therapeutic Targets  | volume = 5 | pages = 23&ndash;40 | doi = 10.1517/14728222.5.1.23 | pmid = 15992166 | issue = 1 }}

{{デフォルトソート:へふちとてほるみらあせ}}
[[Category:EC 3.5.1]]