20α-ヒドロキシステロイドデヒドロゲナーゼのソースを表示

{{enzyme 
| EC_number = 1.1.1.149
| IUBMB_EC_number =  1/1/1/149
| CAS_number= 9040-08-8
| Name =  20α-ヒドロキシステロイドデヒドロゲナーゼ
| GO_code = 0047006
| image =  
| width =  
| caption = 
}}
'''20α-ヒドロキシステロイドデヒドロゲナーゼ'''（20α-hydroxysteroid dehydrogenase）は、次の[[化学反応]]を[[触媒]]する[[酸化還元酵素]]である。
:17α,20α-ジヒドロキシプレグン-4-エン-3-オン + NAD(P)+ <math>\rightleftharpoons</math> 17α-ヒドロキシプロゲステロン + NAD(P)H + H<sup>+</sup>
反応式の通り、この酵素の[[基質]]は[[17α,20α-ジヒドロキシプレグン-4-エン-3-オン]]とNAD(P)<sup>+</sup>、生成物は[[17α-ヒドロキシプロゲステロン]]とNAD(P)HとH<sup>+</sup>である。

組織名は'''20α-hydroxysteroid:NAD(P)<sup>+</sup> 20-oxidoreductase'''で、別名に20α-hydroxy steroid dehydrogenase, 20α-HSD, 20α-HSDHがある。

== 参考文献 ==
* {{cite journal | author = Shikita M, Inano H, Tamaoki B | date = 1967 | title = Further studies on 20-alpha-hydroxysteroid dehydrogenase of rat testes | journal = Biochemistry.  | volume = 6 | pages = 1760&ndash;4  | pmid = 4382486 | doi = 10.1021/bi00858a026 }}
* {{cite journal | author = Strickler RC, Tobias B, Covey DF | date = 1981 | title = Human placental 17 beta-estradiol dehydrogenase and 20 alpha-hydroxysteroid dehydrogenase. Two activities at a single enzyme active site | journal = J. Biol. Chem.  | volume = 256 | pages = 316&ndash;21  | pmid = 6935192 }}
* {{cite journal | author = Wiest WG, Kidwell WR, Balogh K | title = Progesterone catabolism in the rat ovary: a regulatory mechanism for progestational potency during pregnancy | journal = Endocrinology | volume = 82 | issue = 4 | pages = 844–59 | year = 1968 | month = April | pmid = 5742200 | doi = | url = | issn = }}

* {{cite journal | author = Wiest WG | title = On the function of 20 alpha-hydroxypregn-4-en-3-one during parturition in the rat | journal = Endocrinology | volume = 83 | issue = 6 | pages = 1181–4 | year = 1968 | month = December | pmid = 5721991 | doi = | url = | issn = }}

* {{cite journal | author = Piekorz RP, Gingras S, Hoffmeyer A, Ihle JN, Weinstein Y | title = Regulation of progesterone levels during pregnancy and parturition by signal transducer and activator of transcription 5 and 20alpha-hydroxysteroid dehydrogenase | journal = Mol. Endocrinol. | volume = 19 | issue = 2 | pages = 431–40 | year = 2005 | month = February | pmid = 15471942 | doi = 10.1210/me.2004-0302 | url = | issn = }}

* {{cite journal | author = Akinola LA, Poutanen M, Vihko R, Vihko P | title = Expression of 17beta-hydroxysteroid dehydrogenase type 1 and type 2, P450 aromatase, and 20alpha-hydroxysteroid dehydrogenase enzymes in immature, mature, and pregnant rats | journal = Endocrinology | volume = 138 | issue = 7 | pages = 2886–92 | year = 1997 | month = July | pmid = 9202232 | doi = | url = | issn = }}

* {{cite journal | author = Weinstein Y | title = 20alpha-hydroxysteroid dehydrogenase: a T lymphocyte-associated enzyme | journal = J. Immunol. | volume = 119 | issue = 4 | pages = 1223–9 | year = 1977 | month = October | pmid = 302277 | doi = | url = | issn = }}

* {{cite journal | author = Weinstein Y, Lindner HR, Eckstein B | title = Thymus metabolises progesterone- possible enzymatic marker for T lymphocytes | journal = Nature | volume = 266 | issue = 5603 | pages = 632–3 | year = 1977 | month = April | pmid = 300849 | doi = | url = | issn = }}

* {{cite journal | author = Ihle JN, Keller J, Oroszlan S, Henderson LE, Copeland TD, Fitch F, Prystowsky MB, Goldwasser E, Schrader JW, Palaszynski E, Dy M, Lebel B | title = Biologic properties of homogeneous interleukin 3. I. Demonstration of WEHI-3 growth factor activity, mast cell growth factor activity, p cell-stimulating factor activity, colony-stimulating factor activity, and histamine-producing cell-stimulating factor activity | journal = J. Immunol. | volume = 131 | issue = 1 | pages = 282–7 | year = 1983 | month = July | pmid = 6190911 | doi = | url = | issn = }}

* {{cite journal | author = Hershkovitz L, Beuschlein F, Klammer S, Krup M, Weinstein Y | title = Adrenal 20alpha-hydroxysteroid dehydrogenase in the mouse catabolizes progesterone and 11-deoxycorticosterone and is restricted to the X-zone | journal = Endocrinology | volume = 148 | issue = 3 | pages = 976–88 | year = 2007 | month = March | pmid = 17122075 | doi = 10.1210/en.2006-1100 | url = | issn = }}

{{DEFAULTSORT:20ひとろきしすてろいとてひとろけなせ}}
[[Category:EC 1.1.1]]